Use the resources below before or during your submission to identify variables, imaging outputs, or biospecimens relevant to your project. These materials will help you accurately complete your project/data request form.

Analytical Data (Including Neuroimaging)

The 1Florida ADRC provides a wide range of de-identified clinical, cognitive, biomarker, and neuroimaging variables. To request this data, investigators must submit a new project/data request along with IRB approval or an institutional non-human determination letter for review by the 1Florida ADRC Executive Committee.

Once approved, investigators will receive the Quick-Access Dataset, which includes the most frequently requested variables. If additional variables are needed, the Data Core Team will follow up for clarification.

What’s Available?

Core Datasets

• National Alzheimer’s Coordinating Center (NACC) Unified Data Sets
  • UDS-3
  • UDS-4
• 1Florida-specific clinical, psychosocial, and neuropsychological measures
  • 1Florida ADRC Data Dictionary
• Biomarker quantification data (neuroimaging, blood plasma, and genetic)

Neuroimaging Quantification Outputs

• Freesurfer v 7.1.0: subcortical and cortical volumes (Desikan-Killiany Atlas), hippocampal subfields volumes, amygdala nuclei volumes, cortical thickness 
• Free-water diffusion metrics: free water, FA,  fwcFA (Ofori et al., 2019, NeuroImage: Clinical, 24(August)) 
• PET standardized uptake value ratios (SUVRs) (Fang et al., 2020. Methods, 344(July))

Neuroimaging Raw Scans (NIFTI format)

• A listing of scanners and protocols is available here
• T1 (COR MPRAGE/Accelerated Sagittal MPRAGE)
• T2 Star
• T2 Flair
• Diffusion (b = 1000, b=2000)
• Resting-state MRI (rMRI)
• SWI
• ASL

Biospecimen Data

The 1Florida ADRC maintains an active biospecimen bank to support the acquisition, storage, handling, and distribution of well-characterized samples for investigators. Biospecimen samples are linked to MRI and amyloid- and tau-PET imaging, neuropsychological assessments, and emerging biomarkers aimed at detecting the earliest stages of cognitive decline. The ADRC Biospecimen Review Committee meets every other month to review requests for biospecimens. Specimens are housed at the University of Florida, which serves as the 1Florida ADRC biorepository.

What’s Available?

• Plasma
• Serum (limited cohort)
• Buffy coat isolates
• DNA extracts from buffy coats

To request frozen brain tissue or slides from fixed brain tissue, please directly email Dr. Stefan Prokop: sprokop@ufl.edu.

Explore the Data Dictionary

The 1Florida ADRC Quick Access Data Dictionary provides an overview of available variables across clinical, neuropsychological, and biomarker domains. Investigators should consult this resource to identify variables of interest and specify them in the request form. 

• 1FL ADRC De-Identified Data Dictionary
• NACC Forms repository

For questions about data availability after reviewing the data dictionary, or for additional clarification regarding the 1Florida ADRC data, please email Batul Yawer: byawer@ufl.edu.

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